Cardiovascular Impacts of Kidney Diseases

Heart failure, affects the kidney through the backward and the forward failure effects. Systemic Venous congestion results in an increase in the capillary pressure, transudation into interstitial spaces with decrease in effective circulating volume. In addition, underlying conditions that cause renal disease, such as high blood pressure and diabetes, put people at risk for cardiovascular disease. Patients with chronic kidney disease are at considerably increased risk for cardiovascular disease and sudden cardiac death. One mechanism underlying increased cardiovascular risk in patients with renal failure includes over activation of the sympathetic nervous system (SNS). Multiple human and animal studies have shown that central sympathetic outflow is inveterately elevated in patients with each end-stage renal disease (ESRD) and chronic kidney disease (CKD).

  • Anemia
  • Diabetes
  • High blood pressure
  • Calcium-phosphate levels
  • High homocysteine levels

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